4-Aminopyrazolo[3,4-d]pyrimidine

Product Name: 4-Aminopyrazolo[3,4-d]pyrimidine
CAS No.: 2380-63-4
Chemical Name: 4-Aminopyrazolo[3,4-d]pyrimidine
Synonyms: 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE;4-app;4 APP;nsc1393;NSC 1393;4-Aminopyra;Aminopurinol;Pyrazoloadenine;TIMTEC-BB SBB004205;ADENINE ANTIMETABOLITE
CBNumber: CB3112436
Molecular Formula: C5H5N5
Formula Weight: 135.13
MOL File: 2380-63-4.mol

More

Less

4-Aminopyrazolo[3,4-d]pyrimidine Property

Melting point:: >325 °C(lit.)
Boiling point:: 238.81°C (rough estimate)
Density: 1.3795 (rough estimate)
refractive index: 1.7000 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in DMSO
pka: 12.12±0.20(Predicted)
form: powder to crystal
color: White to Orange to Green
Water Solubility: Insoluble in water.
BRN: 5824
InChIKey: LHCPRYRLDOSKHK-UHFFFAOYSA-N
CAS DataBase Reference: 2380-63-4(CAS DataBase Reference)
NIST Chemistry Reference: 1H-pyrazolo[3,4-d]pyrimidin-4-amine(2380-63-4)
EPA Substance Registry System: 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (2380-63-4)

More

Less

Safety

Hazard Codes: T
Risk Statements: 25-36/37/38-23/24/25
Safety Statements: 26-36/37/39-45-22-36
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: UR0717000
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29335990
Toxicity: LD50 oral in rat: 141mg/kg

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: A1041
Product name: 4-Aminopyrazolo[3,4-d]pyrimidine
Purity: >97.0%(HPLC)(T)
Packaging: 100mg
Price: $33
Updated: 2024/03/01

TCI Chemical

Product number: A1041
Product name: 4-Aminopyrazolo[3,4-d]pyrimidine
Packaging: 1G
Price: $44
Updated: 2024/03/01

TCI Chemical

Product number: A1041
Product name: 4-Aminopyrazolo[3,4-d]pyrimidine
Packaging: 5G
Price: $132
Updated: 2024/03/01

Alfa Aesar

Product number: L03519
Product name: 4-Amino-1H-pyrazolo[3,4-d]pyrimidine, 98%
Packaging: 5g
Price: $253.05
Updated: 2023/01/06

Alfa Aesar

Product number: L03519
Product name: 4-Amino-1H-pyrazolo[3,4-d]pyrimidine, 98%
Packaging: 250mg
Price: $23
Updated: 2021/12/16

More

Less

4-Aminopyrazolo[3,4-d]pyrimidine Chemical Properties,Usage,Production

Description

4-aminopyrazolo[3,4-d]pyrimidine (4-APP), the isomer of adenine with the five-membered ring in the pyrazole configuration, is by far the most potent inhibitor of both enzymatic reactions catalyzed by Stx1. It is also a new type of mTOR inhibitor. The 4-aminopyrazolo[3,4-d]pyrimidines, a well-characterized class of compounds for tyrosine kinase inhibition, were used as a Src inhibitor module that blocks the adenosine binding site[1-2].

Chemical Properties

Light Tan Solid

Uses

4-Amino-1H-pyrazolo[3,4-d]pyrimidine decreases serum cholesterol markedly in rats.

References

[1] M Brigotti. “4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1.” Nucleic Acids Research 28 12 (2000): 2383–8.
[2] Ho Jin Lee. “Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity.” Molecular Cancer 17 1 (2018): 50.

4-Aminopyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-Aminopyrazolo[3,4-d]pyrimidine Suppliers

Americas 1 Austria 1 Belgium 1 Canada 2 China 305 Czech Republic 1 Europe 2 France 2 Germany 8 India 23 Japan 3 South Korea 1 Switzerland 2 The Netherlands 2 United Kingdom 13 United States 44 Global 411

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10194
Advantage: 62

Accela ChemBio Inc.

Tel: (+1)-858-699-3322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 19965
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63711
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

Alfa Chemistry

Tel
Email: info@alfa-chemistry.com
Country: United States
ProdList: 2344
Advantage: 58

Aston Chemical

Tel: 13000000000
Email: sales@astonchem.com
Country: United States
ProdList: 1634
Advantage: 58

More

Less

View Lastest Price from 4-Aminopyrazolo[3,4-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4
Price: US $0.01-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50 tons
Release date: 2020-05-19

Nanjing Fred Technology Co., Ltd

Product: 4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-28

Henan Fengda Chemical Co., Ltd

Product: 4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

2380-63-4, 4-Aminopyrazolo[3,4-d]pyrimidineRelated Search:

Zolpidem tartrate Pyraclostrobin Dibenzylamine Triethanolamine Triallylamine 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Bis(2-ethylhexyl)amine 4-AMINOPYRAZOLO(3,4-D)PYRIMIDINE-6-OL Zolpidem 1H-PYRAZOL-4-YLAMINE Aminopyrazine Pyrazine 7-Aminopyrazolo[1,5-a]pyrimidine-3,6-dicarbonitrile 7-aminopyrazolo[1,5-a]pyrimidine-6-carbonitrile 7-aminopyrazolo(4,3-d)pyrimidine 1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-Aminopyrazolo[3,4-d]pyrimidine 7-AMINOPYRAZOLO[1,5-A]PYRIMIDINE-3,6-DICARBOXYLIC ACID

TIMTEC-BB SBB004205

1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE

1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE

4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE

4-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDINE

ADENINE ANTIMETABOLITE

4- aMinopyrazolo [3,4-d] pyriMidines

PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE

4-Amino-1H-pyrazolo[3,4-d]pyrimidine,98%

1(H)-4-amine-pyrazolo[3,4-d]pyrimidine

1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine

4-Aminopyrazolo[3,4-d]pyrimidine 98%

1H-pyrazolo[4,3-e]pyrimidin-4-amine

1H-pyrazolo[4,3-e]pyrimidin-4-ylamine

4-Aminopyrazolo[3,4-<i>d</i>]pyrimidine

4-Aminopyra

1H-Pyrazolo[3,4-d]pyrimidine, 4-amino-

4 APP

4-Aminopyrazole(3,4-d)pyrimidine

4-Aminopyrazolopyrimidine

4-app

4-d)pyrimidine,4-amino-1h-pyrazolo(

NSC 1393

nsc1393

Pyrazoloadenine

1H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI)

Adenine antimetabolite, Pyrazolo[3,4-d]pyrimidin-4-amin

Aminopurinol

4-Amino-1,2,5,7-tetraaza-1H-indene

4-Aminopyrazolo[3,4-d]pyrimidine,98%

4-AMinopyrazolo[3,4-d]pyriMidine, 97.5%

Pyrazolo[3,4-d]pyrimidin-4-amin

4-Aminopyrazolo[3,4-d]pyrimidine &gt

4-Dihydroxybenzylamine hydrobromide

1H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI, ACI)

4-aminopyrazole and [3,4-d] pyrimidine

IbrutinibIntermediate5

2380-63-4

Building Blocks

Heterocyclic Building Blocks

Pyrimidines

Heterocyclic Compounds

Heterocycles

PYRIMIDINE

Pyridines, Pyrimidines, Purines and Pteredines

Heterocycle-Pyrimidine series